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Clustered Dynamics of Inhibitory Synapses and Dendritic Spines in the Adult Neocortex
A key feature of the mammalian brain is its capacity to adapt in response to experience, in part by remodeling of synaptic connections between neurons. Excitatory synapse rearrangements have been monitored in vivo by observation of dendritic spine dynamics, but lack of a vital marker for inhibitory synapses has precluded their observation. Here, we simultaneously…
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In Media
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Inhibitory and Excitatory Synapse Dynamics in the Brain
The brain adapts to the environment in part by persistently modifying and rearranging the diverse synaptic connections between neurons. These changes include strengthening or weakening existing links, as well as forming and eliminating synapses — long-term adjustments that are required for learning and memory. Since excitatory synapses on excitatory neurons are localized to small protrusions…
