Education
- Ph.D. degree from the Faculty of Health Science, University of Copenhagen
Ph.D. thesis performed at the Molecular Neuropharmacology and Genetics Laboratory
Dept. of Neuroscience and Pharmacology, University of Copenhagen
Subject: PDZ domain scaffolding proteins in the CNS
2009 – 2013 - MSc degree from the University of Copenhagen, Candidate in Biochemistry
Master’s thesis performed at the Protein Laboratory
Dept. of Neuroscience and Pharmacology, University of Copenhagen
Subject: The effect of CNTF-derived peptides on cerebellar granular neurons
2005 – 2008 - BSc degree from the University of Copenhagen, Bachelor in Biochemistry
2005
Employment
- Postdoctoral Fellow at the Nedivi Laboratory, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 2013 – present
- Postdoctoral Associate at the Molecular Neuropharmacology and Genetics Laboratory, Dept. of Neuroscience and Pharmacology, University of Copenhagen, 2012 – 2013
- Research assistant at the Molecular Neuropharmacology and Genetics Laboratory, Dept. of Neuroscience and Pharmacology, University of Copenhagen, 2008 – 2009
Selected Publications
- Genomic mapping and cellular expression of human CPG2 transcripts in the SYNE1 gene.
Loebrich S*, Rathje M*, Hager E, Ataman B, Harmin DA, Greenberg ME, Nedivi E.
Mol Cell Neurosci. 2015 Dec 15;71:46-55. (*equally contributed) PubMed Link» View PDF»
- Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.
Erlendsson S*, Rathje M*, Heidarsson PO, Poulsen FM, Madsen KL, Teilum K, Gether U.
J Biol Chem. 2014 Sep 5;289(36):25327-40. Epub 2014 Jul 13. (*equally contributed)
- AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons.
Rathje M, Fang H, Bachman JL, Anggono V, Gether U, Huganir RL, Madsen KL.
Proc Natl Acad Sci U S A, 2013 Aug 27;110(35):14426-31. Epub 2013 Aug 12.
- Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, Rønn LC, Gether U.
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8. Epub 2009 Dec 14.
